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16 channel multi electrode array  (NeuroNexus Technologies)
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NeuroNexus Technologies 16 channel multi electrode array
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
16 Channel Multi Electrode Array, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hts probe  (World Precision Instruments)
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World Precision Instruments hts probe
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
Hts Probe, supplied by World Precision Instruments, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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shank multi array electrode  (NeuroNexus Technologies)
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NeuroNexus Technologies shank multi array electrode
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
Shank Multi Array Electrode, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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polyamide electrode arrays  (NeuroNexus Technologies)
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NeuroNexus Technologies polyamide electrode arrays
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
Polyamide Electrode Arrays, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a sic electrodes against similar  (NeuroNexus Technologies)
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NeuroNexus Technologies a sic electrodes against similar
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
A Sic Electrodes Against Similar, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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16 channel silicone linear array electrodes  (NeuroNexus Technologies)
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NeuroNexus Technologies 16 channel silicone linear array electrodes
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
16 Channel Silicone Linear Array Electrodes, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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32 channel linear electrode  (NeuroNexus Technologies)
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NeuroNexus Technologies 32 channel linear electrode
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
32 Channel Linear Electrode, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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64 channel electrode arrays  (NeuroNexus Technologies)
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NeuroNexus Technologies 64 channel electrode arrays
(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a <t>Neuronexus</t> <t>16-channel</t> recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.
64 Channel Electrode Arrays, supplied by NeuroNexus Technologies, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a Neuronexus 16-channel recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.

Journal: bioRxiv

Article Title: Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

doi: 10.64898/2026.01.13.699312

Figure Lengend Snippet: (A) Representative image of multi-unit recordings setup of ex vivo thalamic horizontal slices in a humidified, oxygenated interface chamber. (B) Schematic of multi-unit activity recordings with a Neuronexus 16-channel recording electrode positioned in the thalamus following electrical stimulation of the internal capsule. (C) Representative 3-second recording of intrathalamic multi-unit activity evoked by stimulation of the internal capsule (black dot indicates time of stimulation). Only 12 of 16 channels are shown for clarity. (D) Collapsed activity from 12 recording channels in (C). Black dot indicates time of stimulation. (E) Post-stimulus time histogram of instantaneous spiking frequency from multi-unit activity recorded across 16 channels (all 16 channels were analyzed, 12 representative channels are displayed in (C) from 15 slices from 9 hCSF1 (WT) mice, 8 slices from 7 hCSF1-Grn −/− +KOxMG mice, and 12 slices from 9 hCSF1-Grn −/− +WTxMG mice. The grey box denotes early response (0–1.5 s), and the white box denotes delayed response (1.5–3 s) after stimulation. (F) Enlarged instantaneous frequency of the delayed response (1.5–3 s) from (D). (G) Relative probability of eliciting spiking during the direct response (0–1.5 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (* p = 0.0024). (H) Instantaneous frequency of spiking during the early response (0–1.5 s) after stimulation; Kruskal–Wallis test, H(3) = 6.767, p = 0.0797. (I) Relative probability of eliciting spiking during the delayed response (1.5–3 s) after stimulation; p values from Kolmogorov-Smirnov test with Bonferroni correction (**** p < 0.0001). (J) Instantaneous frequency of spiking during the delayed response (1.5–3 s) after stimulation; Kruskal-Wallis test, H(3)=56.6, **** p < 0.0001, and Dunn’s multiple comparisons test (**** p < 0.0001). Data are presented as mean ± SEM. Comparisons not shown are not significant.

Article Snippet: Extracellular multi-unit activity (MUA) recordings were obtained with a linear 16-channel multi-electrode array (Neuronexus) that spanned the nRT and VB thalamic regions.

Techniques: Ex Vivo, Activity Assay